Spicatulides A-G, Phenolic-Monoterpenoid Hybrids from Chloranthus spicatus .

Spicatulides A-G ( 1 - 7 ), seven new phenolic-monoterpenoid hybrid molecules, along with two known compounds, 8 and 9 , were isolated and identified from Chloranthus spicatus . Compound 1 represents an unprecedented skeleton featuring an aryl-fused 2-oxabicyclo[4.3.1]decane moiety, and compound 2 is the first example of a denudaquinol-normonoterpenoid adduct. Their structures with absolute configurations were elucidated on the basis of spectroscopic data analyses and TDDFT-ECD calculations. Compounds 3 , 5 , 6 , and 9 exhibited the activity of reducing lipogenesis in HepG2 cells in a dose-dependent manner.