Factors that confound the prediction of renal medullary oxygenation and risk of acute kidney injury from measurement of bladder urine oxygen tension.
Jennifer P NgoYugeesh R LankadevaMichael Z L ZhuAndrew MartinMonica KankiAndrew D CochraneJulian A SmithAmanda G ThriftClive N MayRoger G EvansPublished in: Acta physiologica (Oxford, England) (2019)
uPO2 provides a robust estimate of mPO2 , but this relationship is confounded by the simultaneous presence of systemic hyperoxia and low urine flow. Urine flow increases and uPO2 decreases during CPB. Thus, CPB is probably the best time to use uPO2 to detect renal medullary hypoxia and risk of post-operative AKI.