Selective binding of an organoruthenium complex to G-rich human telomeric sequence by tandem mass spectrometry.
Yiyu ChengWenjuan ZengYang ChengJishuai ZhangTao ZouKui WuFuyi WangPublished in: Rapid communications in mass spectrometry : RCM (2018)
This is the first report of using top-down MS to characterize the interactions of organometallic ruthenium(II) complexes and human telomeric DNA. Thymine can be thermodynamically competitive with guanine for binding to ruthenium complexes even at low reaction molar ratio, which inspired us to explore in greater depth the significance of thymine binding.
Keyphrases
- tandem mass spectrometry
- endothelial cells
- liquid chromatography
- high performance liquid chromatography
- ultra high performance liquid chromatography
- induced pluripotent stem cells
- simultaneous determination
- mass spectrometry
- multiple sclerosis
- dna damage response
- ms ms
- solid phase extraction
- circulating tumor
- single molecule
- cell free
- binding protein
- transcription factor
- dna repair