Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-κB pathways.

Huahong YangHongming LvHaijun LiXinxin CiXinxin Ci

Published in: Cell communication and signaling : CCS (2019)

Our results demonstrated that Ori exerted protective effects on LPS-induced ALI via Nrf2-independent anti-inflammatory and Nrf2-dependent antioxidative activities.

Keyphrases

oxidative stress
lps induced
anti inflammatory
inflammatory response
diabetic rats
ischemia reperfusion injury
signaling pathway
dna damage
induced apoptosis
nuclear factor
toll like receptor
heat shock
pi k akt
endoplasmic reticulum stress