Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk Starting at Pediatric Age.
Elisa RussoGiovanna LeonciniPasquale EspositoGiacomo GaribottoRoberto PontremoliFrancesca ViazziPublished in: International journal of molecular sciences (2020)
Recently, there has been a growing interest in epidemiological and clinical studies supporting a pathogenetic role of fructose in cardio-metabolic diseases, especially in children and adolescents. In the present review, we summarize experimental data on the potential biological mechanisms linking fructose and uric acid in the development of insulin resistance, metabolic syndrome, obesity, diabetes, hypertension, non-alcoholic fatty liver disease and chronic renal disease, thereby contributing to an increase in cardiovascular risk at pediatric age.
Keyphrases
- uric acid
- metabolic syndrome
- insulin resistance
- cardiovascular disease
- type diabetes
- cardiovascular risk factors
- high fat diet
- high fat diet induced
- blood pressure
- glycemic control
- polycystic ovary syndrome
- electronic health record
- weight loss
- skeletal muscle
- risk assessment
- machine learning
- coronary artery disease
- weight gain
- liver fibrosis
- arterial hypertension