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Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation.

Drayton C HarveyPrashan De ZoysaOmar ToubatJongkyu ChoiJahnavi KishoreHidekazu TsukamotoS Ram Kumar
Published in: Birth defects research (2021)
Our model recapitulates the increased incidence of OFT alignment defects seen in the clinic due to PAE. The presence of a concomitant SHF genetic mutation increases the incidence of PAE-related OFT defects. An apparent synergistic interaction between PAE and the loss of DLL4-mediated Notch signaling in OFT alignment requires further analysis.
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