Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys.

Takahisa YoshikawaAkiko OguchiNaoya ToriuYuki Sato Takashi KobayashiOsamu OgawaHironori Haga Satoko Sakurai Takuya Yamamoto Yasuhiro Murakawa Motoko Yanagita

Published in: Journal of the American Society of Nephrology : JASN (2023)

These findings suggest that TLTs potentially amplify inflammation by providing a microenvironment that allows intense interactions between renal parenchymal and immune cells. These interactions may serve as novel therapeutic targets in kidney diseases involving TLT formation.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
stem cells
gene expression
endoplasmic reticulum stress
cell death
pi k akt