Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys.
Takahisa YoshikawaAkiko OguchiNaoya ToriuYuki SatoTakashi KobayashiOsamu OgawaHironori HagaSatoko SakuraiTakuya YamamotoYasuhiro MurakawaMotoko YanagitaPublished in: Journal of the American Society of Nephrology : JASN (2023)
These findings suggest that TLTs potentially amplify inflammation by providing a microenvironment that allows intense interactions between renal parenchymal and immune cells. These interactions may serve as novel therapeutic targets in kidney diseases involving TLT formation.