Therapeutic targeting of transcriptional elongation in diffuse intrinsic pontine glioma.

Hiroaki KatagiNozomu TakataYuki AoiYongzhan ZhangEmily J RendlemanGavin T BlythFrank D EckerdtYusuke TomitaTakahiro SasakiAmanda M SaratsisAkihide KondoStewart GoldmanOren J BecherEdwin SmithLihua ZouAli ShilatifardRintaro Hashizume

Published in: Neuro-oncology (2021)

SEC disruption by KL-1 increased therapeutic benefit in vitro and in vivo, supporting a potential therapeutic activity of KL-1 in H3K27M-mutant DIPG.

Keyphrases

gene expression
transcription factor
low grade
cancer therapy
oxidative stress
heat shock