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Activation of the sweet taste receptor T1R3 by sucralose attenuates VEGF-induced vasculogenesis in a cell model of the retinal microvascular endothelium.

Polina LizunkovaEmmanuella EnuwosaHavovi Chichger
Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2018)
These studies are the first to demonstrate a protective effect of an artificial sweetener, through the sweet taste receptor T1R3, on VEGF-induced vasculogenesis in a retinal microvascular endothelial cell line.
Keyphrases
  • endothelial cells
  • high glucose
  • optical coherence tomography
  • diabetic rats
  • vascular endothelial growth factor
  • diabetic retinopathy
  • nitric oxide
  • cell therapy
  • oxidative stress
  • bone marrow