Facile fabrication of a magnetically smart PTX-loaded Cys-Fe3O4/CuS@BSA nano-drug for imaging-guided chemo-photothermal therapy.
Lanfang RenXi-Jian LiuQian WangLijuan ZhangGuoying DengFeng ZhouJie LuPublished in: Dalton transactions (Cambridge, England : 2003) (2018)
In this study, a multifunctional nano-drug (PTX-loaded Cys-Fe3O4/CuS@BSA nanocomposite), which performs well in hydrophobic drug delivery, magnetic resonance imaging (MRI) and chemo-photothermal combination therapy, has been successfully synthesized via a facile method with several biocompatible agents. The characterization verified that our as-obtained nanocarrier has a preferable average diameter of about 300 nm for cancer therapy, shows a great MRI ability and magnetism performance, and exhibits a favorable in vitro and in vivo photothermal therapeutic efficacy by introducing CuS, and the sustained release of chemotherapeutics could be controlled by pH value and near-infrared laser irradiation has further enhanced the therapeutic performance. Overall, the excellent synergistic effect to inhibit tumor growth effectively realized via imaging-guided combinational chemo-photothermal therapy in the present work, highlights the promise of conquering the limitations of tumor treatments.
Keyphrases
- cancer therapy
- drug delivery
- magnetic resonance imaging
- combination therapy
- drug release
- contrast enhanced
- high resolution
- reduced graphene oxide
- photodynamic therapy
- quantum dots
- diffusion weighted imaging
- highly efficient
- ionic liquid
- visible light
- metal organic framework
- fluorescence imaging
- radiation therapy
- emergency department
- optic nerve
- squamous cell carcinoma
- drug induced
- radiation induced
- big data
- deep learning
- solid phase extraction
- high speed