A probabilistic method for leveraging functional annotations to enhance estimation of the temporal order of pathway mutations during carcinogenesis.
Menghan WangTianxin YuJinpeng LiuLi ChenArnold J StrombergJohn L VillanoSusanne M ArnoldChunming LiuChi WangPublished in: BMC bioinformatics (2019)
PATOPA provides a useful tool to estimate temporal order of mutations at the pathway level while leveraging functional annotations of mutations.
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