The Impact of CB1 Receptor on Inflammation in Skeletal Muscle Cells.

Published in: Journal of inflammation research (2021)

For the first time, a unique link between ACEA and IL-6 up-regulation has been established; IL-6 up-regulation generated by ACEA is mediated in skeletal muscle through cannabinoid CB1 receptor activation. As a result, cannabinoid CB1 receptors may be useful pharmaceutical targets in the treatment of inflammation and related disorders in skeletal muscle tissues.

Keyphrases

skeletal muscle
insulin resistance
oxidative stress
induced apoptosis
gene expression
cell cycle arrest
type diabetes
metabolic syndrome
cell death
endoplasmic reticulum stress
adipose tissue
signaling pathway
cell proliferation