Manipulation of the Myc Interactome to Enhance Nerve Regeneration in a Murine Model.

Trevor M PoitrasPrashanth KomirishettyAparna AretiMatt LaroucheAnand KrishnanAmbika ChandrasekharEaston MunchrathDouglas W Zochodne

Published in: Annals of neurology (2024)

Members of the Myc interactome, specifically Mad1, are novel targets for improving nerve regeneration. Unleashing of Myc growth signaling through Mad1 KD enhances the regrowth of both peripheral neurons and SCs to facilitate better regrowth of nerves. ANN NEUROL 2024;96:216-230.

Keyphrases

stem cells
transcription factor
peripheral nerve
spinal cord
wound healing
chemotherapy induced