ATR Inhibition Potentiates the Radiation-induced Inflammatory Tumor Microenvironment.
Magnus T DillonKatharina F BergerhoffMalin PedersenHarriet WhittockEva Crespo-RodriguezEmmanuel C PatinAlex PearsonHenry G SmithJames T E PagetRadhika R PatelShane FooGalabina BozhanovaChanthirika RagulanElisa FontanaKrisha DesaiAnna C WilkinsAnguraj SadanandamAlan MelcherMartin McLaughlinKevin J HarringtonPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
We show that DNA damage by ATRi and RT leads to an IFN response through activation of nucleic acid-sensing pathways. This triggers increased antigen presentation and innate immune cell infiltration. Further understanding of the effect of this combination on the immune response may allow modulation of these effects to maximize tumor control through antitumor immunity.