A TOMM40/APOE allele encoding APOE-E3 predicts high likelihood of late-onset Alzheimer's disease in autopsy cases.

Selma M SoyalMarkus KwikOgnian KalevStefan LenzGreta ZaraPeter StrasserWolfgang PatschSerge Weis

Published in: Molecular genetics & genomic medicine (2020)

The striking association of TOMM40 only with high likelihood AD may explain some contrasting results for TOMM40 in clinical studies and may reflect an association with more advanced disease and/or suggest a role of TOMM40 in the pathogenesis of neurofibrillary tangles.

Keyphrases

late onset
cognitive decline
early onset
high fat diet
mild cognitive impairment
type diabetes
metabolic syndrome
adipose tissue
insulin resistance