Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis.

Jane L Tarry-AdkinsImogen D GrantSusan E OzanneRebecca M ReynoldsCatherine E Aiken

Published in: Diabetes therapy : research, treatment and education of diabetes and related disorders (2021)

Our results demonstrate equal efficacy of longer-acting formulations (met-XR, met-DR) versus immediate-release metformin formulations in terms of glycaemic control. There were insufficient studies available to compare the efficacy of different metformin formulations outside of diabetes care. However met-XR was associated with reduced serum LDL cholesterol concentrations, while met-DR was strongly associated with reduced GI side effects, which could improve drug compliance.

Keyphrases

tyrosine kinase
type diabetes
low density lipoprotein
drug induced
case control