Apoptosis in ischemic heart disease.
Elena TeringovaPetr TousekPublished in: Journal of translational medicine (2017)
Apoptosis plays an important role in the myocardial loss after acute myocardial infarction and participates in the process of subsequent left ventricular remodeling and development of symptomatic heart failure. Finding a sensitive apoptotic marker that would help in prognostic stratification of patients after acute myocardial infarction and offer new therapeutic strategies is thus of a great importance. Several studies suggest that tumor necrosis factor-related apoptosis inducing ligand (TRAIL) represents a very promising marker of prognosis in patients with acute myocardial infarction. This review article provides an overview of current knowledge on the role of apoptosis in ischemic heart disease and highlights potentially beneficial apoptotic markers in clinical practice.
Keyphrases
- acute myocardial infarction
- left ventricular
- cell death
- cell cycle arrest
- heart failure
- endoplasmic reticulum stress
- oxidative stress
- percutaneous coronary intervention
- end stage renal disease
- clinical practice
- cardiac resynchronization therapy
- hypertrophic cardiomyopathy
- chronic kidney disease
- newly diagnosed
- ejection fraction
- healthcare
- mitral valve
- rheumatoid arthritis
- aortic stenosis
- prognostic factors
- coronary artery disease
- signaling pathway
- anti inflammatory
- patient reported