Identification of p.Met215Ile mutation of the MC4R gene in a Moroccan woman with obesity.
Meriem El FessikhHakim BelghitiZouhair ElkarhatHassania GuerinechNadia DakkaJamila E I BaghdadiPublished in: Clinical case reports (2021)
Screening the MC4R gene showed one rare mutation p.Met215Ile in a Moroccan patient with morbid obesity, which leads to a change in the protein structure. The analysis of MC4R variants may be useful for future therapeutic approaches.
Keyphrases
- copy number
- insulin resistance
- weight loss
- metabolic syndrome
- type diabetes
- high fat diet induced
- genome wide
- case report
- weight gain
- tyrosine kinase
- bariatric surgery
- genome wide identification
- dna methylation
- adipose tissue
- protein protein
- gene expression
- small molecule
- body mass index
- obese patients
- binding protein
- transcription factor
- amino acid
- physical activity