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Integrative multi-omics analysis identifies genetically supported druggable targets and immune cell specificity for myasthenia gravis.

Jiao LiFei WangZhen LiJingjing FengYi MenJinming HanJiangwei XiaChen ZhangYilai HanTeng ChenYinan ZhaoSirui ZhouYuwei DaGuoliang ChaiJunwei Hao
Published in: Journal of translational medicine (2024)
This study provides crucial insights into the genetic and molecular factors associated with MG susceptibility, singling out CTSH as a potential candidate for in-depth investigation and clinical consideration. It additionally sheds light on the immune-cell regulatory mechanisms related to the disease. However, further research is imperative to validate these targets and evaluate their feasibility for drug development.
Keyphrases
  • myasthenia gravis
  • genome wide
  • transcription factor
  • single cell
  • gene expression
  • dna methylation
  • network analysis