Emodin inhibits bladder inflammation and fibrosis in mice with interstitial cystitis by regulating JMJD3.

Cristina Pires Camargo Marita Saliba Elio Assaad Saad Yongsheng Zhu José Mauricio Caldera Mingwei Huang Songtao Luo Hai Tang

Published in: Acta cirurgica brasileira (2023)

Our study reveals the critical role of emodin-JMJD3 signaling in interstitial cystitis by regulating inflammation, fibrosis, and extracellular matrix deposition in cells and tissues, and these findings provide an avenue for effective treatment of patients with cystitis.

Keyphrases

extracellular matrix
oxidative stress
induced apoptosis
spinal cord injury
cell cycle arrest
gene expression
type diabetes
cell death
high fat diet induced
signaling pathway
combination therapy
skeletal muscle