Post-mortem analysis of dolutegravir, tenofovir, lamivudine and efavirenz penetration in multiple CNS compartments.

Fan WangKara RademeyerOlivie C NamujuKizito AbdusalaamuJames FisherDavid B MeyaMaryPeace McRaeDavid R BoulwareRobert LukandeMelanie R Nicol

Published in: The Journal of infectious diseases (2024)

Analysis of postmortem tissue provides a unique opportunity to investigate CNS antiretroviral penetration. Regional differences were observed paving the way to identify mechanisms of viral compartmentalization and/or neurotoxicity.

Keyphrases

hiv infected patients
antiretroviral therapy
hiv infected
human immunodeficiency virus
hiv positive
blood brain barrier
hiv aids
sars cov
hepatitis c virus