Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis.
Tsegaye DeyouMakungu MarcoMatthias HeydenreichFangfang PanAmra GruhonjicPaul A FitzpatrickAndreas KochSolomon DereseJerry PelletierKari T RissanenAbiy YenesewMáté ErdélyiPublished in: Journal of natural products (2017)
A new isoflavone, 8-prenylmilldrone (1), and four new rotenoids, oblarotenoids A-D (2-5), along with nine known compounds (6-14), were isolated from the CH2Cl2/CH3OH (1:1) extract of the leaves of Millettia oblata ssp. teitensis by chromatographic separation. The purified compounds were identified by NMR spectroscopic and mass spectrometric analyses, whereas the absolute configurations of the rotenoids were established on the basis of chiroptical data and in some cases by single-crystal X-ray crystallography. Maximaisoflavone J (11) and oblarotenoid C (4) showed weak activity against the human breast cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8 μM, respectively.
Keyphrases
- high resolution
- room temperature
- endothelial cells
- solid state
- molecular docking
- magnetic resonance
- essential oil
- electronic health record
- induced pluripotent stem cells
- oxidative stress
- breast cancer cells
- big data
- liquid chromatography
- dual energy
- young adults
- mass spectrometry
- cell proliferation
- signaling pathway
- artificial intelligence
- machine learning
- molecular dynamics simulations
- breast cancer risk