Glycocalixarene with luminescence for Warburg effect-mediated tumor imaging and targeted drug delivery.

Yang LiShengnan LiuMin LiangYujun CuiHongxia Zhao Qingzhi Gao

Published in: Chemical communications (Cambridge, England) (2021)

Fluorescently labeled calix[4]arene glycoconjugates demonstrate multifunctional potential in both Warburg effect mediated tumor imaging and GLUT1 targeted drug delivery. Nitrobenzoxadiazole and mannose conjugated NBD-Man-CA was found to be selectively recognized by GLUT1 and act as a "molecular carrier" for selective tumor targeting.

Keyphrases

drug delivery
cancer therapy
high resolution
photodynamic therapy
computed tomography