Two Fatal Cases of Acute Liver Failure Due to HSV-1 Infection in COVID-19 Patients Following Immunomodulatory Therapies.

Stefano BusaniAndrea BediniEmanuela BiagioniLucia SerioRoberto TonelliMarianna MeschiariErica FranceschiniGiovanni GuaraldiAndrea CossarizzaEnrico CliniAntonino MaioranaWilliam GennariNicola De MariaMario LuppiCristina MussiniMassimo Girardisnull null

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)

We report two fatal cases of acute liver failure secondary to herpes simplex virus 1 infection in COVID-19 patients, following tocilizumab and corticosteroid therapy. Screening for and prompt recognition of herpes simplex virus 1 reactivation in these patients, undergoing immunomodulatory treatment, may have potentially relevant clinical consequences.

Keyphrases

liver failure
herpes simplex virus
hepatitis b virus
patients undergoing
sars cov
rheumatoid arthritis
juvenile idiopathic arthritis
stem cells