Pain sensitivity and analgesic use among 10,486 adults: the Tromsø study.
Per-Jostein SamuelsenChristopher Sivert NielsenTom WilsgaardAudun StubhaugKristian SvendsenAnne Elise EggenPublished in: BMC pharmacology & toxicology (2017)
Increased pain sensitivity was associated with analgesic use in general, and reduced pain tolerance was found for both opioid and non-opioid analgesic users. The data suggest that hyperalgesia is an effect of analgesics, whereas pain tolerance has little impact on future analgesic use.