Semaphorins: From Angiogenesis to Inflammation in Rheumatoid Arthritis.
Jerome AvouacSonia PezetEloïse VandebeuqueCindy OrvainVirginie GonzalezGrégory MarinGaël MouterdeClaire DaïenYannick AllanorePublished in: Arthritis & rheumatology (Hoboken, N.J.) (2021)
Gene expression profiling of ECs identified class 3 and class 4 semaphorins as potential biomarkers and therapeutic candidates in RA, with confirmed overexpression in ECs, synovial vessels, and serum, and correlation with validated markers of inflammation and angiogenesis. Thus, semaphorins might be novel and appealing EC-derived inflammatory and proangiogenic targets in RA.
Keyphrases
- rheumatoid arthritis
- oxidative stress
- disease activity
- endothelial cells
- genome wide
- ankylosing spondylitis
- vascular endothelial growth factor
- interstitial lung disease
- genome wide identification
- cell proliferation
- copy number
- transcription factor
- wound healing
- systemic lupus erythematosus
- systemic sclerosis
- genome wide analysis