Impaired autophagy in myeloid cells aggravates psoriasis-like skin inflammation through the IL-1β/CXCL2/neutrophil axis.
Jinju LeeMi-Yeon KimHyo Jeong KimWoo Sun ChoiHyo Jung LeePublished in: Cell & bioscience (2024)
Our results suggest that autophagy dysfunction in myeloid cells, especially macrophages, along with IL-1β dysregulation has a causal role in neutrophilic inflammation and psoriasis pathogenesis.