A longitudinal epigenome-wide association study of preeclamptic and normotensive pregnancy.

Shuwei Liu Haoyi Fu Mitali Ray Lacey W Heinsberg Yvette P Conley Cindy M Anderson Carl A Hubel James M Roberts Arun Jeyabalan Daniel E Weeks Mandy J Schmella

Published in: Epigenetics communications (2023)

) were validated with a new platform but were not replicated in an independent sample. Given the differences in participant characteristics between the discovery and replication samples, we cannot rule out important signals for these CpGs. Additional research is warranted for cg16155413/cg21882990, as well as top hits in trimesters 1-2 and significant DMRs that were not examined in the replication phase.

Keyphrases

high throughput
dna methylation
small molecule
preterm birth
gene expression
pregnancy outcomes