Anti-Melanogenic and Antioxidant Activity of Bifidobacterium longum Strain ZJ1 Extracts, Isolated from a Chinese Centenarian.
Jing WuFuna ZhangHaixia YuShimei QiYu WuWeihua XiaoPublished in: International journal of molecular sciences (2023)
Melanin produced by melanocytes protects our skin against ultraviolet (UV) radiation-induced cell damage and oxidative stress. Melanin overproduction by hyperactivated melanocytes is the direct cause of skin hyperpigmentary disorders, such as freckles and melasma. Exploring natural whitening agents without the concern of toxicity has been highly desired. In this study, we focused on a Bifidobacterium longum strain, ZJ1, isolated from a Chinese centenarian, and we evaluated the anti-melanogenic activity of the distinctive extracts of ZJ1. Our results demonstrated that whole lysate (WL) and bacterial lysate (BL) of ZJ1 ferments efficiently reduce α-melanocyte-stimulating hormone (α-MSH)-induced melanin production in B16-F10 cells as well as the melanin content in zebrafish embryos. BL and WL downregulate melanogenesis-related gene expression and indirectly inhibit intracellular tyrosinase activity. Furthermore, they both showed antioxidant activity in a menadione-induced zebrafish embryo model. Our results suggest that ZJ1 fermentation lysates have application potential as therapeutic reagents for hyperpigmentary disorders and whitening agents for cosmetics.
Keyphrases
- oxidative stress
- radiation induced
- diabetic rats
- gene expression
- induced apoptosis
- high glucose
- soft tissue
- radiation therapy
- drug induced
- dna methylation
- single cell
- wound healing
- endoplasmic reticulum stress
- dna damage
- ischemia reperfusion injury
- cell therapy
- endothelial cells
- pregnant women
- risk assessment
- signaling pathway
- climate change
- aqueous solution