Epileptogenic Tubers Are Associated with Increased Kurtosis of Susceptibility Values: A Combined Quantitative Susceptibility Mapping and Stereoelectroencephalography Pilot Study.
Aswin ChariJ SedlacikK SeunarineRory J PiperP HalesKarin ShmueliKshitij MankadU LöbelC EltzeFriederike MoellerR C ScottMartin M TisdallJudith Helen CrossD W CarmichaelPublished in: AJNR. American journal of neuroradiology (2023)
Our finding of increased kurtosis of quantitative susceptibility mapping values (heavy-tailed distribution) was highly specific, suggesting that it may be a useful biomarker to identify putative epileptogenic tubers in tuberous sclerosis complex. This finding motivates the investigation of underlying tuber mineralization and other properties driving kurtosis changes in quantitative susceptibility mapping values.