Alterations of Left Ventricular Function Persisting during Post-Acute COVID-19 in Subjects without Previously Diagnosed Cardiovascular Pathology.
Mariana TudoranCristina TudoranVoichita Elena LazureanuAdelina Raluca MarinescuNicusor Gheorghe PopAlexandru Silvius PescariuAlexandra EnacheTalida Georgiana CutPublished in: Journal of personalized medicine (2021)
(1) Background: Coronavirus infection (Covid-19) has emerged as a severe medical condition, associated with high pulmonary morbidity and often with cardiovascular (CV) complications. This study aims to evidence the persistence of left ventricular (LV) systolic function (LV-SF) alterations and diastolic dysfunction (DD) in COVID-19 patients without history of cardiovascular (CV) diseases by transthoracic echocardiography (TTE). (2) Methods: 125 patients, aged under 55 years, hospitalized during the first outbreak of Covid-19 for moderate pneumonia, underwent a comprehensive cardiologic examination and TTE at 6-10 weeks after discharge. Their initial in-hospital laboratory data and thorax computer tomography (TCT) were accessed from the electronic database of the hospital. (3) Results: with TTE, we documented alterations of LV-SF and DD in 8.8% of patients and in 16.8% only patterns of DD, statistically correlated with the initial levels of creatin-kinase (CK-MB) and inflammatory factors. Multivariate regression analysis evidenced that CK-MB levels, age, and body mass index (BMI) are responsible for 65% of LV-SF decrease. (4) Conclusions: Alterations of LV-SF and DD are frequent in post-acute COVID-19 infection and are responsible for the persistence of symptoms. Elevated myocardial necrosis markers during the acute phase seem to predict subsequent alteration of cardiac performance.
Keyphrases
- left ventricular
- sars cov
- coronavirus disease
- body mass index
- ejection fraction
- end stage renal disease
- newly diagnosed
- aortic stenosis
- healthcare
- acute myocardial infarction
- cardiac resynchronization therapy
- blood pressure
- chronic kidney disease
- hypertrophic cardiomyopathy
- prognostic factors
- respiratory syndrome coronavirus
- big data
- mitral valve
- drug induced
- pulmonary hypertension
- oxidative stress
- acute coronary syndrome
- weight loss
- emergency department
- weight gain
- depressive symptoms
- adverse drug
- patient reported outcomes
- deep learning
- electronic health record
- physical activity
- atrial fibrillation
- sleep quality
- early onset
- gestational age