Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy.

Katsunori YogoMasaki MisawaMorihito ShimizuHidetoshi ShimizuTomoki KitagawaRyoichi HirayamaHiromichi IshiyamaTakako FurukawaHiroshi Yasuda

Published in: International journal of nanomedicine (2021)

+AuNPs at low concentrations displayed stronger radiosensitization compared to -AuNPs. Combining +AuNPs with 192Ir γ-rays in HDR brachytherapy is a candidate method for improving clinical outcomes. Future development of cancer cell-specific +AuNPs would allow their wider application for HDR brachytherapy.

Keyphrases

high dose
dna damage
stem cell transplantation
low dose
escherichia coli
radiation therapy
oxidative stress
dna repair
current status
crispr cas
squamous cell carcinoma
locally advanced