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Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy.

Katsunori YogoMasaki MisawaMorihito ShimizuHidetoshi ShimizuTomoki KitagawaRyoichi HirayamaHiromichi IshiyamaTakako FurukawaHiroshi Yasuda
Published in: International journal of nanomedicine (2021)
+AuNPs at low concentrations displayed stronger radiosensitization compared to -AuNPs. Combining +AuNPs with 192Ir γ-rays in HDR brachytherapy is a candidate method for improving clinical outcomes. Future development of cancer cell-specific +AuNPs would allow their wider application for HDR brachytherapy.
Keyphrases
  • high dose
  • dna damage
  • stem cell transplantation
  • low dose
  • escherichia coli
  • radiation therapy
  • oxidative stress
  • dna repair
  • current status
  • crispr cas
  • squamous cell carcinoma
  • locally advanced