Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy.
Katsunori YogoMasaki MisawaMorihito ShimizuHidetoshi ShimizuTomoki KitagawaRyoichi HirayamaHiromichi IshiyamaTakako FurukawaHiroshi YasudaPublished in: International journal of nanomedicine (2021)
+AuNPs at low concentrations displayed stronger radiosensitization compared to -AuNPs. Combining +AuNPs with 192Ir γ-rays in HDR brachytherapy is a candidate method for improving clinical outcomes. Future development of cancer cell-specific +AuNPs would allow their wider application for HDR brachytherapy.