MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells.

Yujuan XiongLin WangWenyi JiangLihua PangWeihua LiuAiqun LiYun ZhongWenchao OuBenrong LiuShi-Ming Liu

Published in: BMC molecular biology (2019)

MEF2A knockdown accelerates HCAEC senescence, and the underlying molecular mechanism may be involved in down-regulation of the genes related with cell proliferation, development, inflammation and survival, in which PIK3CG may play a key role.

Keyphrases

endothelial cells
oxidative stress
cell proliferation
high glucose
dna damage
genome wide
coronary artery
coronary artery disease
vascular endothelial growth factor
signaling pathway
genome wide identification
gene expression
copy number
stress induced
aortic stenosis
genome wide analysis