Reduced Synaptic Density in Patients with Lewy Body Dementia: An [11 C]UCB-J PET Imaging Study.
Katrine B AndersenAllan K HansenMalene F DamholdtJacob HorsagerCasper SkjaerbaekHanne GottrupHenriette KlitAnna Christina SchachtErik H DanielsenDavid J BrooksPer BorghammerPublished in: Movement disorders : official journal of the Movement Disorder Society (2021)
Widespread cortical reduction of synaptic density was documented in a cohort of DLB/PDD subjects using in vivo [11C]UCB-J PET. Our study confirms previously reported synaptic loss in SN of nPD patients. [11C]UCB-J binding in selected cortical VOIs of the DLB/PDD patients correlated with their levels of cognitive function across relevant neuropsychological domains. These findings suggest that the loss of synaptic density contributes to cognitive impairment in nPD and DLB/PDD. © 2021 International Parkinson and Movement Disorder Society.