Evaluation of KP-1199: a novel acetaminophen analog for hemostatic function and antinociceptive effects.

Kristin M Reddoch-CardenasBopaiah P CheppudiraThomas GarzaChad D HopkinsKevin D BunkerDeborah H SleeAndrew P CapJames A BynumRobert J Christy

Published in: Transfusion (2021)

These results suggest that KP-1199 possesses antinociceptive activity in a rat model of thermal injury. Since KP-1199 does not induce platelet activation or inhibit coagulation, it presents an attractive alternative to APAP for analgesia, especially for battlefield or surgical scenarios where blood loss and blood clotting are of concern.

Keyphrases

anti inflammatory
climate change
pain management
ultrasound guided
liver injury
chronic pain