Nutraceutical Properties of Polyphenols against Liver Diseases.
Jorge SimonMaría Casado-AndrésNaroa Goikoetxea-UsandizagaMarina Serrano-MaciáMaría Luz Martínez-ChantarPublished in: Nutrients (2020)
Current food tendencies, suboptimal dietary habits and a sedentary lifestyle are spreading metabolic disorders worldwide. Consequently, the prevalence of liver pathologies is increasing, as it is the main metabolic organ in the body. Chronic liver diseases, with non-alcoholic fatty liver disease (NAFLD) as the main cause, have an alarming prevalence of around 25% worldwide. Otherwise, the consumption of certain drugs leads to an acute liver failure (ALF), with drug-induced liver injury (DILI) as its main cause, or alcoholic liver disease (ALD). Although programs carried out by authorities are focused on improving dietary habits and lifestyle, the long-term compliance of the patient makes them difficult to follow. Thus, the supplementation with certain substances may represent a more easy-to-follow approach for patients. In this context, the consumption of polyphenol-rich food represents an attractive alternative as these compounds have been characterized to be effective in ameliorating liver pathologies. Despite of their structural diversity, certain similar characteristics allow to classify polyphenols in 5 groups: stilbenes, flavonoids, phenolic acids, lignans and curcuminoids. Herein, we have identified the most relevant compounds in each group and characterized their main sources. By this, authorities should encourage the consumption of polyphenol-rich products, as most of them are available in quotidian life, which might reduce the socioeconomical burden of liver diseases.
Keyphrases
- peritoneal dialysis
- end stage renal disease
- liver failure
- drug induced
- liver injury
- physical activity
- risk factors
- hepatitis b virus
- metabolic syndrome
- cardiovascular disease
- weight loss
- public health
- emergency department
- drinking water
- chronic kidney disease
- ejection fraction
- extracorporeal membrane oxygenation
- newly diagnosed
- electronic health record
- liver fibrosis