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Early-life antibiotic use and risk of asthma and eczema: results of a discordant twin study.

Elise Margaretha Adriana SlobBronwyn K BrewSusanne J H VijverbergChantal J A R KatsCristina LongoMariëlle W PijnenburgToos C E M van BeijsterveldtConor V DolanMeike BartelsPatrick MagnussonPaul LichtensteinTong GongGerard H KoppelmannCatarina AlmqvistDorret I BoomsmaAnke H Maitland-van der Zee
Published in: The European respiratory journal (2020)
Children exposed to early-life antibiotic use, particularly prescribed for respiratory infections, may be at higher risk of asthma. This risk can still be observed when correcting for genetic and environmental factors. Our results could not elucidate whether the relationship between early-life antibiotic use and eczema is confounded by familial and genetic factors.
Keyphrases
  • early life
  • chronic obstructive pulmonary disease
  • lung function
  • genome wide
  • allergic rhinitis
  • atopic dermatitis
  • young adults
  • copy number
  • cystic fibrosis
  • dna methylation
  • gene expression