The role of interleukin 17 in Crohn's disease-associated intestinal fibrosis.
Paolo BiancheriSylvia Lf PenderFrancesca AmmoscatoPaolo GiuffridaGianluca SampietroSandro ArdizzoneAmir GhanbariRenata CurciarelloAlessandra PasiniGiovanni MonteleoneGino R CorazzaThomas T MacdonaldAntonio Di SabatinoPublished in: Fibrogenesis & tissue repair (2013)
Our results suggest that IL-17A, but not IL-17E, is pro-fibrotic in CD. Further studies are needed to clarify whether the therapeutic blockade of IL-17A through the anti-IL-17A monoclonal antibody secukinumab is able to counteract the fibrogenic process in CD.