Development of alginate/chitosan hydrogel loaded with obestatin and evaluation of collagen type I, III, VEGF and TGF-β 1 gene expression for skin repair in a rat model (in vitro and in vitro study).

Nazanin ToumajMajid Salehi Sepehr ZamaniZohreh ArabpourAli R DjalianMajid Rahmati

Published in: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2024)

The present study suggests that 3D Alg/Cs hydrogels with a concentration of 100 µM obestatin have the potential for clinical application in the treatment of skin injuries.

Keyphrases

wound healing
drug delivery
gene expression
tissue engineering
dna methylation
epithelial mesenchymal transition
drug release
smoking cessation