Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells.

Rosi BissingerPolina Petkova-KirovaOlga MykhailovaPer-Arne OldenborgElena NovikovaDavid A DonkorThomas DietzAbdulla Al Mamun BhuyanWilliam P SheffieldMarijke GrauFerruh ArtuncLars KaestnerJason P AckerSyed M Qadri

Published in: Cell communication and signaling : CCS (2020)

Taken together, our data unravel a new role for TSP-1/CD47 signaling in mediating Ca2+ influx into RBCs, a mechanism potentially contributing to their dysfunction in a variety of systemic diseases. Video abstract.

Keyphrases

red blood cell
endothelial cells
oxidative stress
electronic health record
machine learning
free survival
data analysis
drug induced