Three neurosteroids as well as GABAergic drugs do not convert immediate postictal potentiation to depression in immature rats.
Pavel MarešEva KudováKarel ValešHana KubováPublished in: Pharmacological reports : PR (2020)
Our results support a role of GABA in augmentation of cortical after discharges after longer intervals, whereas immediate postictal potentiation is not affected by GABAergic drugs. Due to similar effect with GABAergic drugs, the main mechanism of action of the three steroids tested is potentiation of GABAergic inhibition.