Delivery of MSCs with a Hybrid β-Sheet Peptide Hydrogel Consisting IGF-1C Domain and D-Form Peptide for Acute Kidney Injury Therapy.

Hongfeng WangYuna ShangXiaoniao ChenZhongyan WangDashuai ZhuYue LiuChuyue ZhangPu ChenJie WuLingling WuDeling KongZhimou YangZongjin Li Xiang-Mei Chen

Published in: International journal of nanomedicine (2020)

This hydrogel could provide a favorable niche for hP-MSCs and thereby rescue renal function in an AKI model by promoting cell survival and angiogenesis. In conclusion, by covalently linking the desired functional groups to D-form peptides to create functional hydrogels, self-assembling β-sheet peptide hydrogels may serve as a promising platform for tissue-engineering and stem cell therapy.

Keyphrases

tissue engineering
cell therapy
acute kidney injury
mesenchymal stem cells
drug delivery
wound healing
hyaluronic acid
cardiac surgery
stem cells
umbilical cord
endothelial cells
high throughput
bone marrow
binding protein