Login / Signup

Serious Long-Term Effects of Head and Neck Cancer from the Survivors' Point of View.

Katherine J TaylorCecilie D AmdalKristin BjordalGuro L AstrupBente B HerlofsonFréderic DuprezRicardo Ribeiro GamaAlexandre Arthur JacintoEva HammerlidMelissa ScriccioloFemke JansenIrma M Verdonck-de LeeuwGiuseppe FanettiOrlando Guntinas-LichiusJohanna InhesternTatiana DraganAlexander FabianAndreas BoehmUlrike WöhnerNaomi KiyotaMaximilian KrügerPierluigi BonomoMonica PintoSandra NuytsJoaquim Castro SilvaCarmen StrombergerFrancesco TramacereAyman BushnakPietro PerottiMichaela PlathAlberto PadernoNoa StemplerMaria KouriSusanne Singer
Published in: Healthcare (Basel, Switzerland) (2023)
The long-term problems of head and neck cancer survivors (HNCS) are not well known. In a cross-sectional international study aimed at exploring the long-term quality of life in this population, 1114 HNCS were asked to state their two most serious long-term effects. A clinician recorded the responses during face-to-face appointments. A list of 15 example problems was provided, but a free text field was also available. A total of 1033 survivors responded to the question. The most frequent problems were 'dry mouth' (DM) ( n = 476; 46%), 'difficulty swallowing/eating' (DSE) ( n = 408; 40%), 'hoarseness/difficulty speaking' (HDS) ( n = 169; 16%), and 'pain in the head and neck' (PHN) ( n = 142; 14%). A total of 5% reported no problems. Logistic regression adjusted for age, gender, treatment, and tumor stage and site showed increased odds of reporting DM and DSE for chemo-radiotherapy (CRT) alone compared to surgery alone (odds ratio (OR): 4.7, 95% confidence interval (CI): 2.5-9.0; OR: 2.1, CI: 1.1-3.9), but decreased odds for HDS and PHN (OR: 0.3, CI: 0.1-0.6; OR: 0.2, CI: 0.1-0.5). Survivors with UICC stage IV at diagnosis compared to stage I had increased odds of reporting HDS (OR: 1.9, CI: 1.2-3.0). Laryngeal cancer survivors had reduced odds compared to oropharynx cancer survivors of reporting DM (OR: 0.4, CI: 0.3-0.6) but increased odds of HDS (OR: 7.2, CI: 4.3-12.3). This study provides evidence of the serious long-term problems among HNCS.
Keyphrases