Exploring novel capping framework: high substituent pyridine-hydroxamic acid derivatives as potential antiproliferative agents.

Fernando Hernández-BorjaItzel Mercado-SánchezYolanda AlcarazMarco A García-RevillaClarisa Villegas GómezDavid Ordaz-RosadoNancy Santos-MartínezRocío García-BecerraMiguel A Vázquez

Published in: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (2021)

The synthesized compounds 2-thiophene (15j) and 2-furan (15k) pyridine displayed cell growth inhibition, regulation of genes related to cell cycle progression in highly metastatic cancer cell lines. The molecular coupling analysis performed with HDAC1, HDAC6 and HDAC8 showed an increment in the number of interactions performed by the capping moiety and consequently in the strength of the capping group interaction.

Keyphrases

cell cycle
histone deacetylase
cell proliferation
papillary thyroid
squamous cell carcinoma
small cell lung cancer
genome wide
squamous cell
risk assessment
ionic liquid
data analysis