The Role of Genetics in Clinically Suspect Arthralgia and Rheumatoid Arthritis Development: A Large Cross-Sectional Study.
Marc P MauritsFenne WoutersEllis NiemantsverdrietThomas W J HuizingaErik B van den AkkerSaskia Le CessieAnnette H M van der Helm-van MilRachel KnevelPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
We observed that genetic predisposition increased across pre-RA participant groups. The RA PRS differed in early classified RA and inflammatory pre-disease stages, regardless of ACPA stratification. HLA-SE prevalence differed between arthritis patients, particularly ACPA+ patients, and healthy controls. Genetics seem to fulfill different etiologic roles.
Keyphrases
- rheumatoid arthritis
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- disease activity
- peritoneal dialysis
- risk factors
- gene expression
- oxidative stress
- interstitial lung disease
- systemic lupus erythematosus
- systemic sclerosis
- copy number
- genome wide
- idiopathic pulmonary fibrosis
- patient reported