Persistence of SARS-CoV-2 nasopharyngeal swab PCR positivity in COVID-19 convalescent plasma donors.

Sachie IkegamiRobert BenirschkeTara FlanaganNicole TannaTovah KleinRita EluePatricia DeboszJessica MallekGregory WrightPerry GuarigliaJason KangThomas J Gniadek

Published in: Transfusion (2020)

SARS-CoV-2 nucleic acid is detectable long after the resolution of symptoms in a significant percentage of previously diagnosed individuals, which is important to consider when interpreting PCR swab results. Persistence of PCR positivity does not correlate with antibody strength or symptoms of COVID-19. If anti-spike antibody is used to assess CP potency, individuals who suffered severe COVID-19 disease symptoms may represent better donors.

Keyphrases

sars cov
respiratory syndrome coronavirus
nucleic acid
coronavirus disease
real time pcr
early onset
single molecule
physical activity