Self-reactive T cells induce and perpetuate chronic relapsing arthritis.

Jonatan TuncelJens HolmbergSabrina HaagMalin Hultqvist HopkinsLena Wester-RosenlöfStefan CarlsenPeter OlofssonRickard Holmdahl

Published in: Arthritis research & therapy (2020)

These findings show that, once activated, self-reactive T cells can sustain inflammatory responses for extended periods of time and suggest that such responses are promoted in the presence of IL-17.

Keyphrases

multiple sclerosis
rheumatoid arthritis
disease activity