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Self-reactive T cells induce and perpetuate chronic relapsing arthritis.

Jonatan TuncelJens HolmbergSabrina HaagMalin Hultqvist HopkinsLena Wester-RosenlöfStefan CarlsenPeter OlofssonRickard Holmdahl
Published in: Arthritis research & therapy (2020)
These findings show that, once activated, self-reactive T cells can sustain inflammatory responses for extended periods of time and suggest that such responses are promoted in the presence of IL-17.
Keyphrases
  • multiple sclerosis
  • rheumatoid arthritis
  • disease activity