Fecal calprotectin is a reliable marker of endoscopic response to vedolizumab therapy: A simple algorithm for clinical practice.

Renske Wilhelmina Maria PauwelsAnnemarie Charlotte de VriesChristien Janneke van der Woude

Published in: Journal of gastroenterology and hepatology (2020)

This prospective study demonstrates a significant correlation between FC and endoscopic response to VDZ. FC < 200 μg/g prognosticate endoscopic response, and FC > 450 μg/g endoscopic non-response. An increase in FC of > 400 μg/g after induction indicates endoscopic loss of response. This simple FC algorithm may guide clinical decisions on the continuation and optimization of VDZ in inflammatory bowel disease patients.

Keyphrases

ultrasound guided
machine learning
end stage renal disease
endoscopic submucosal dissection
chronic kidney disease
ejection fraction
rheumatoid arthritis
mesenchymal stem cells
cell therapy
replacement therapy