SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells.

Rocío Seoane Tomás Lama-Díaz Antonia María Romero Ahmed El Motiam Arantxa Martínez-Férriz Santiago Vidal Yanis H Bouzaher María Blanquer Rocío M Tolosa Juan Castillo Mewa Manuel S Rodriguez Adolfo García-Sastre Dimitris P Xirodimas James D Sutherland Rosa Barrio Paula Alepúz Miguel G Blanco Rosa Farràs Carmen Rivas

Published in: Cellular & molecular biology letters (2024)

SUMO2 conjugation to eIF5A is a stress-induced response implicated in the adaptation of yeast cells to heat-shock stress and required to promote the growth and migration of pancreatic ductal adenocarcinoma cells.

Keyphrases

induced apoptosis
stress induced
cell cycle arrest
heat shock
endoplasmic reticulum stress
signaling pathway
cell proliferation
saccharomyces cerevisiae