iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors.
Margarita E BogomiakovaElizaveta K SekretovaKsenia S AnufrievaPolina O KhabarovaAnastasia N KazakovaPavel A BobrovskyTatiana V GrigoryevaArtem V EremeevOlga S LebedevaAlexandra N BogomazovaMaria A LagarkovaPublished in: Stem cell research & therapy (2023)
In summary, we showed that iPSC-derived cells can be sensitive to the cytotoxic potential of autologous NK-cells regardless of HLA-I status. Thus, the balance of ligands for NK-cell receptors should be considered prior to iPSC-based cell therapies. Trial registration Not applicable.